p97: The Cell's Molecular Purgatory?

Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway?

Cdc48 (p97), a conserved chaperone-like ATPase of eukaryotic cells, has attracted attention recently because of its wide range of cellular functions. Cdc48 is intimately linked to the ubiquitin pathway because its primary action is to segregate ubiquitinated substrates from unmodified partners. This 'segregase' activity is crucial for certain proteasomal degradation pathways and for some nonpro...

P97: Motor Vehicle Accident During the Pregnancy

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Christmas in purgatory: a retrospective look.

A Protestant Purgatory: Theological Origins of the Penitentiary Act, 1779

25 years ago, in a provocative reconsideration of English political and social history, English Society 1688–1832, J. C. D. Clark advanced the then contentious claim that until the end of the long 18th century England remained what he styled a ‘confessional state’.(1) Missing from the wave of prior work by social and political historians of 18th-century England, Clark argued, was a close attent...

A Protestant Purgatory: Theological Origins of the Penitentiary Act, 1779

25 years ago, in a provocative reconsideration of English political and social history, English Society 1688–1832, J. C. D. Clark advanced the then contentious claim that until the end of the long 18th century England remained what he styled a ‘confessional state’.(1) Missing from the wave of prior work by social and political historians of 18th-century England, Clark argued, was a close attent...